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Cdr2 (S. pombe)
Cdr2 is a serine/threonine protein kinase mitotic regulator in the fission yeast S. pombe. It is encoded by the P87050 2247 bp ORF on the cosmid 57A10. The protein is 775 amino acids in length. Cdr2 is a member of the GIN4 family of kinases, which prevent progression of mitosis if there is a problem with septin. The N-terminus contains a sequence characteristic of serine/threonine protein kinase activity. The C-terminus, while non-catalytic, is necessary for proper localization of Cdr2 during interphase.
Cdr2 null constructs behave similarly to wild-type constructs; the only difference being a slight delay into mitosis and consequently, cells are slightly larger than in wild-type constructs. Therefore, Cdr2 is non-essential. Cdr2 regulates mitotic entry through direct inhibition of Wee1, which is then unable to continue to Cdk1 and subsequently start mitosis.
== Cell localization ==
During interphase (G1, S, G2), Cdr2 is localized in a wide medial band that is centered on the nucleus. The C-terminus is required for correct localization; cleavage of any number of residues close to the carboxy terminus results in abnormal distribution. Pom1 phosphorylates Cdr2 on the C-terminus, and prevents it from spreading beyond the medial band. The width of the cortical band increases proportionately with the length of the growing cell; the final limit is at approximately 30% of the total cell length before the cell enters mitosis. When the cell enters mitosis, Cdr2 is distributed diffusely through the cytoplasm; there is no detectable cortical band in metaphase in anaphase. During septation at the end of anaphase, Cdr2 localizes to the contractile ring. After cytokinesis, Cdr2 is again distributed in a broad medial band centered on the nucleus.
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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